Behavioral effects of maternal separation and early weaning

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This reference is used to annotate "I would never send my kids to school" (2017) by Piotr Wozniak

A new protocol of maternal separation with early weaning has been shown to result in behavioral changes in rodents:

[abridged] the standard 3 h of maternal separation of rat pups results in later alterations in hypothalamic-pituitary-adrenal axis (HPA) functioning, along with perturbations in several behavioral domains including fearfulness, attention, and anxiety. [...] Early weaning itself has been shown to cause neuroendocrine alterations and increased anxiety-like and aggressive behavior in mice [...] The forced swim test is a commonly used test of depressive-like behavior, where mice are forced into an inescapable situation and time spent immobile is considered a measure of behavioral despair. Anti-depressants have been shown to alter activity, specifically leading to a reduction in time spent immobile. [For animals using the novel protocol of separation and weaning] using a 15 min test, we found significant effects of time on almost all measures analyzed


Quoted excerpts come from the following reference:

Title: Maternal separation with early weaning: a novel mouse model of early life neglect

Link: http://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-11-123

Backlink: Maternal separation