Fasting recapitulates the benefits of calorie restriction

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Using a series of feeding regimens, we dissect the effects of calories and fasting, and proceed to demonstrate that fasting alone recapitulates many of the physiological and molecular effects of CR

In his criticism of the presented paper, Prof Sir Stephen O’Rahilly observed interestingly:

This is interesting but very hard to extrapolate to humans. Given the striking differences between mice and humans in the speed at which the body’s processes happen, a comparable human experiment would need to have humans eat all the calories they need for a week in a single day and then starve for the next 6 days. As mice live about 2 years and we now live to around 80, we might have to do the study for more than 50 years to test whether such a massive change to our eating habits actually benefited human longevity

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Quoted excerpts come from the following reference:

Title: Fasting drives the metabolic, molecular, and geroprotective effects of a calorie restricted diet in mice

Date: 2021

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544824/

Backlink: Optimum diet